What was the first FDA approved hyaluronic acid for dermal filling?

Restylane was indeed the first hyaluronic acid-based dermal filler approved by the FDA, marking a significant milestone in aesthetic medicine. Approved in 2003, Restylane set the standard for subsequent hyaluronic acid fillers by demonstrating safety and efficacy for restoring volume and smoothing facial wrinkles and folds. Its unique formulation allows for the natural integration into the tissue, providing a soft, flexible outcome which enhances the overall aesthetic result.

Juvéderm, Belotero, and Radiesse are also popular dermal fillers used in aesthetics, but they were introduced to the market after Restylane. Juvéderm, for instance, was FDA approved later in 2006, while Belotero received approval in 2011. Radiesse is not a hyaluronic acid filler; rather, it's composed of calcium hydroxylapatite microspheres, which is a different substance with a unique application in cosmetic procedures. Thus, Restylane holds the distinction of being the first hyaluronic acid product to gain FDA clearance for dermal filling.