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A common appearance of herpes simplex indeed manifests as red, painful blisters or bumps. This is characteristic of the herpes virus, particularly during an active outbreak. The initial infection typically presents with clusters of small, fluid-filled blisters that are often painful. These blisters can occur on any mucous membrane, but are most frequently observed around the mouth (oral herpes) or the genital area (genital herpes).

The painful and blistering nature of the lesions is due to the body's immune response to the virus, leading to inflammation in the area. As the blisters eventually break and then crust over, the healing process can sometimes be mistaken for other skin conditions, but the initial presentation of red, painful blisters is distinctly associated with herpes simplex. This clarity in presentation allows for effective diagnosis and management options to be considered in clinical practice.

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